Multivalent Glycosheets for Double Light Driven Therapy of Multidrug-Resistant Bacteria on Wounds

With the evergrowing threat posed by multidrug resistance of bacteria, the development of effective antibacterial agents remains a global challenge. Infection with multidrug-resistant bacteria in hospitals significantly impairs the healing of wounds caused by deep-burn injuries or diabetic foot ulceration, leading to a high mortality rate among these patients. A multivalent glycosheet for the double light-driven therapy against multidrug-resistant Pseudomonas aeruginosa (P. aeruginosa) infection on wounds is developed here. Galactose- and fucose-based ligands are self-assembled to form a glyco-layer on the surface of thin-layer molybdenum disulfide, producing the glycosheets capable of selectively localizing P. aeruginosa through multivalent carbohydrate-lectin interactions. The glycosheets loaded with antibiotics have proven applicable for: 1) near-infrared-light driven, in situ thermal release of antibiotics, increasing bacterial membrane permeability, and 2) white light-driven reactive-oxygen-species production to more thoroughly kill the bacteria. The targetability, together with the light sensibility, of the glycosheets enables a highly effective and optically controlled therapeutic regime for the healing of wounds infected by multidrug-resistant as well as clinically isolated P. aeruginosa.