期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 14, 页码 13069-13078出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b21762
关键词
bio-nanoprobe; magnetic resonance imaging; fluorescence; bimodal imaging; magnetic nanoparticles; manganese(II) oxide MnO
资金
- NSERC
- Alberta Innovates-Health Solutions (Collaborative Research and Innovation Opportunities grant) - Canada First Research Excellence Fund
- Canadian Foundation for Innovation (John Evans Leader Fund)
- University of Calgary (Eyes High Fellowship)
- University of Calgary (T. Chen Fong Postdoctoral Fellowship in Medical Imaging)
Multimodal probes are an asset for simplified, improved medical imaging. In particular, fluorescence and magnetic resonance imaging (MM) are sought-after combined capabilities. Here, we show that pyrrolidin-2-one-capped manganese oxide nanoparticles (MnOPyrr NPs) combine MM with fluorescence microscopy to function as efficient bifunctional bio-nanoprobes. We employ a one-pot synthesis for ca. 10 nm MnO NPs, wherein manganese(II) 2,4-pentadionate is thermally decomposed using pyrrolidin-2-one as a solvent and capping ligand. The MnOPyrr NPs are soluble in water without any further postsynthetic modifications. The r(1) relaxivity and r(2)/r(1) ratio indicate that these NPs are potential T-1 MRI contrast agents at clinical (3 T) and ultrahigh (9.4 T) magnetic fields. Serendipitously, the as-prepared NPs are photoluminescent. The unexpected luminescence is ascribed to the modification of the pyrrolidin-2-one during the thermal treatment. MnOPyrr NPs are successfully used to enable fluorescence microscopy of HeLa cells, demonstrating bifunctional imaging capabilities. A low cytotoxic response in two distinct cell types (HeLa, HepG2) supports the suitability of MnOPyrr NPs for biological imaging applications.
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