期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 12, 页码 11227-11237出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b01655
关键词
aggregation-induced emission; wide color tuning; mitochondrial imaging; bacterial imaging; photosensitizer
资金
- National Natural Science Foundation of China [21672135, 21402115, 51403122]
- Natural Science Foundation of Shaanxi Province [2018JM5086]
- Young Talent fund of University Association for Science and Technology in Shaanxi [2017030021]
- Fundamental Research Funds for the Central Universities [GK201702002, GK201902006]
Recently, luminogens with the aggregation-induced emission characteristic (AIEgens) have received much attention in the field of bioimaging and therapeutic applications. However, the development of AIEgens that are derived from the simple core skeleton with emission color tuning for imaging and therapy is still a formidable challenge. To address this constraint, we present a series of cationic AIEgens based on cyanopyridinium salts (CP1-CP5). The AIEgens can be facilely prepared by varying the aromatic electron donor while fixing the cyanopyridinium group as the electron acceptor within a single benzene ring. The obtained AIEgens possess wide color tunability, large Stokes shifts, and bright emission in the condensed state. Due to their good biocompatibility and cationic nature, these AIEgens can be utilized for multiple-color imaging of intracellular mitochondria as well as Gram-negative and Gram-positive bacteria. Importantly, these AIEgens exhibit remarkable structure-dependent singlet-oxygen generation ability under white light illumination (25 mW cm(-2)), and CP4 was optimized to serve as an excellent photosensitizer for photodynamic anticancer and antibacterial therapy.
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