期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 11, 页码 10452-10461出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b18648
关键词
Fe3O4 nanoparticles; superparamagnetic; Astragalus polysaccharides; iron deficiency anemia; magnetic resonance imaging
资金
- National Basic Research Program of China [2015CB921502]
- National Science Foundation of China [51671019, 51731003, 81471725]
- Beijing science and technology Nova cross program [Z171100001117136]
- MOST 13th Five Year National Key Research Project of China [2016YFC1300402]
Iron deficiency anemia (IDA) is a common nutritional disease suffered by 1 billion people. To develop a new drug which avoids the side effects of traditional oral iron supplementation for IDA treatment, we have designed Fe3O4@Astragalus polysaccharide core shell nanoparticles (Fe3O4@APS NPs) and demonstrated them to be an efficient therapeutic drug for IDA treatment in vivo. The Fe3O4@APS NPs have been successfully synthesized with good water solubility and stability, especially in imitated digestion. Cytotoxicity assessment in cells and pathological tests in mice justify their good biocompatibility and low toxicity. The IDA treatment in rats shows that they have efficient therapeutic effect, which is contributed to both the iron element supplement from Fe3O4 and the APS-stimulated hematopoietic cell generation. Moreover, the superparamagnetic Fe3O4@APS NPs are capable for use as a magnetic resonance imaging contrast agent. This study presents the possibility of nanocomposites involving purified natural products from Chinese herb medicine for biomedical applications.
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