期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 10, 页码 9872-9883出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b22336
关键词
Nanocrystal aggregates; Nanomedicine; Self-assembly; Carrier-free; Synergetic antitumor effects
资金
- National Natural Science Foundation of China [81501583, 81601592]
- National Key R&D Program of China [2018YFC1313400]
- China Post-doctoral Science Foundation [2015M582795]
- Chongqing Post-doctoral Science Special Foundation [xm2015091]
Carrier-free nanomedicines mainly composed of drug nanocrystals are considered as promising candidates for next-generation nanodrug formulations. However, such nanomedicines still need to be stabilized by additive surfactants, synthetic polymers, or biologically based macromolecules. Based on the strong intermolecular interactions between indomethacin (IDM, a COX-2 inhibitor) and paclitaxel (PTX, a chemotherapy drug), we herein successfully engineered a novel kind of carrier-free nanomedicines that organized as IDM-induced PTX nanocrystal aggregates via one-pot self-assembly without any nonactive excipients. In the assemblies of IDM and PTX (IDM/PTX assemblies), PTX nanocrystals were tasted with amorphous IDM molecules, like a brick-cement architecture. In serum, these nanoassemblies could rapidly collapse into a great number of smaller nanoparticles, thus targeting the tumor site through the EPR effect. Under the assistance of IDM on immunotherapy, the IDM/PTX assemblies showed obviously improved synergetic antitumor effects of immunotherapy and chemotherapy. The self-assembly of two synergistic active substances into nanomedicines without any nonactive excipients might open an alternative avenue and give inspiration to fabricate novel carrier-free nanomedicines in many fields.
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