期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 10, 页码 9832-9840出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b00074
关键词
carbon dots; fluorescent; gynostemma; bioimaging; antioxidant; zebrafish
资金
- Research on the Ultrafine Oxide Regenerated Cellulose Hemostatic Materials from Application Technology Research and Development of Harbin Science and Technology Bureau [2017RAQXJ039]
- National Natural Science Foundation of China [31701296, 11474076]
- Open Project of State Key Laboratory of Urban Water Resources and Water Environment, Harbin Institute of Technology [ES201702]
Fluorescent carbon dots (CDs) have been synthesized via the calcination method using natural gynostemma as the precursor, without any toxic ingredients or surface passivation chemicals. CDs have a narrow size distribution, and the mean particle size is about 2.5 nm. CDs exhibit good water dispersibility and can emit intense blue fluorescence under 365 nm UV light in an aqueous solution, which can be stable in different conditions. The biotoxicity of CDs on the embryonic development of zebrafish is evaluated, the hatch rate and survival rate of embryos are around 90%, and the malformation rate is less than 10%. Because of the excellent fluorescence stability and biocompatibility, CDs can be used in zebrafish for bioimaging. In addition, the antioxidative stress property of CDs is investigated both in vitro and in vivo, and the presence of CDs can promote the mRNA expression of related genes to encode more antioxidant proteins in zebrafish. Therefore, fluorescent CDs would be a potential candidate for bioimaging and treating diseases caused by excessive oxidation damage, such as cancer, senility, and other diseases associated with aging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据