期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 8, 页码 7725-7730出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.8b19658
关键词
aminosaccharide; gold nanoparticles; multidrug-resistant bacteria; antibacterial activity; biofilm
资金
- Natural Science Foundation of Shandong Province [ZR201709250460]
- Chinese Academy of Sciences [XDA09030305, 121D11KYSB20170026]
- National Science Foundation of China [81361140345, 21535001, 81730051, 21761142006]
Bacterial infection, especially multidrug-resistant (MDR) bacteria-induced wound infection, is an enormous challenge and is the result of the inability of traditional antibiotics to combat MDR bacteria produced by the abuse of broad-spectrum drugs. Here, we present multivalent aminosaccharide-based gold nanoparticles (AuNPs) to remedy the superbug-infected wound. We synthesized multivalent aminosaccharide-based AuNPs via a straightforward method using D-glucosamine (G1uN) to modify gold nanoparticles (AuNPs) as reported. This kind of multivalent aminosaccharide-based AuNP (Au_GluN) can lower the bacterial viability in a mature biofilm that may lead to antibiotic resistance. Au_GluN is innocuous not only for erythrocytes in vitro but also for mice. Moreover, it displays an outstanding ability for superbug-infected wound healing. Such a material provides new candidates to treat bacteria in the clinic.
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