期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 38, 期 8, 页码 1104-1108出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b15-00361
关键词
neuroprotectant; central nervous system; neuronal damage
资金
- Japan Society for the Promotion of Science (JSPS) [15K06781]
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [15K06781] Funding Source: KAKEN
Functions of the central nervous system (CNS) are based on a complex neural network. It is believed that the CNS has several neuroprotective mechanisms operated by neurons, glia and other types of cells against various types of neuronal damage. Since mature, differentiated neurons are not able to divide, it is important to protect neurons from damage prior to death. The neuroprotective effects of a number of pharmaceutical agents and natural products against necrosis and apoptosis of the CNS neurons have been reported, thus this review will mainly discuss several endogenous neuroprotectants and their mechanisms.
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