期刊
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
卷 59, 期 2, 页码 87-95出版社
WILEY
DOI: 10.1002/ajim.22558
关键词
World Trade Center attack, 2001; mortality; occupational exposure; epidemiology; cohort study
资金
- National Institute of Environmental Health Sciences [K01 ES019156]
- National Institute for Occupational Safety and Health [U10-OH008216/23/25/32/39/75, 200-2011-39356/61/77/84/85/88]
Background Rescue and recovery workers responding to the 2001 collapse of the World Trade Center (WTC) sustained exposures to toxic chemicals and have elevated rates of multiple morbidities. Methods Using data from the World Trade Center Health Program and the National Death Index for 2002-2011, we examined standardized mortality ratios (SMR) and proportional cancer mortality ratios (PCMR) with indirect standardization for age, sex, race, and calendar year to the U.S. general population, as well as associations between WTC-related environmental exposures and all-cause mortality. Results We identified 330 deaths among 28,918 responders (SMR 0.43, 95%CI 0.39-0.48). No cause-specific SMRs were meaningfully elevated. PCMRs were elevated for neoplasms of lymphatic and hematopoietic tissue (PCMR 1.76, 95%CI 1.06-2.75). Mortality hazard ratios showed no linear trend with exposure. Conclusions Consistent with a healthy worker effect, all-cause mortality among responders was not elevated. There was no clear association between intensity and duration of exposure and mortality. Surveillance is needed to monitor the proportionally higher cancer mortality attributed to lymphatic/hematopoietic neoplasms. (C) 2016 Wiley Periodicals, Inc.
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