期刊
AMERICAN JOURNAL OF HYPERTENSION
卷 30, 期 1, 页码 81-87出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajh/hpw117
关键词
artery stiffness; blood pressure; cardiovascular risk factors; hypertension; pulse wave velocity; subclinical atherosclerosis; subclinical hypothyroidism; thyroid dysfunction
资金
- Brazilian Ministry of Health (Science and Technology Department)
- Brazilian Ministry of Science and Technology (Financiadora de Estudos e Projetos) [01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ]
- Brazilian Ministry of Science and Technology (CNPq National Research Council) [01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ]
BACKGROUND There is little available data on carotid-femoral pulse wave velocity (cf-PWV) in subjects with subclinical hypothyroidism (SCH). We aimed to analyze the association between SCH and cf-PWV using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). METHODS We included subjects with normal thyroid function (thyrotropin (TSH): 0.4-4.0 mIU/l, and normal free thyroxine (FT4: 0.8-1.9ng/dl) and SCH (TSH > 4.0 mIU/l and normal FT4) evaluated for cf-PWV in a crosssectional analysis. We excluded individuals using medications that interfere in thyroid function, antihypertensives, or diuretics, and subjects with chronic kidney disease or previous cardiovascular disease. Generalized linear and logistic regression models evaluated cf-PWV as a dependent variable and SCH as an independent variable, adjusted for cardiovascular risk factors. RESULTS Of 8,341 subjects (52.3% women), 7,878 (94.4%) were euthyroid and 463 (5.6%) showed SCH. The median age was 50 years (interquartile range: 44-56). The groups differed by age, sex, body mass index, glomerular filtration rate, and C-reactive protein. SCH was not associated with cf-PWV in the full-adjusted linear model (beta = -0.039; P = 0.562) and with cf-PWV > 75th percentile in the full-adjusted logistic model (odds ratio = 0.94; 95% confidence interval = 0.72-1.22). CONCLUSION In a large sample, SCH was not associated with increased cf-PWV.
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