期刊
BIOINFORMATICS
卷 32, 期 4, 页码 632-634出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btv617
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资金
- ERC Advanced Grant
- iMED grant
- DKFZ Postdoc Fellowship
Motivation: Genetic screens by CRISPR/Cas9-mediated genome engineering have become a powerful tool for functional genomics. However, there is currently a lack of end-to-end software pipelines to analyze CRISPR/Cas9 screens based on next generation sequencing. Results: The CRISPR-AnalyzeR for pooled screens (caRpools) is an R package for exploratory data analysis that provides a complete workflow to analyze CRISPR/Cas9 screens. To further support the analysis of large-scale screens, caRpools integrates screening documentation and generation of standardized analysis reports.
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