期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 103, 期 2, 页码 629S-634S出版社
OXFORD UNIV PRESS
DOI: 10.3945/ajcn.114.103986
关键词
lipid emulsions; liver disease; parenteral lipids; PNALD; fish oil; soybean oil; intestinal failure
资金
- Boston Children's Hospital Surgical Foundation, Boston, Massachusetts
- NIH [F32DK104525-01]
- Joshua Ryan Rappaport Fellowship
Long-term parenteral nutrition (PN) carries the risk of progressive liver disease in infants with intestinal failure. Although PN-associated liver disease (PNALD) is multifactorial in etiology, components of soybean oil lipid emulsions have been implicated in the disease's pathogenesis. Historically, infants with PNALD who were unable to wean from PN to full enteral feeding developed cirrhosis and end-stage liver disease, which require liver transplantation to survive. Over the past 2 decades, novel strategies for the management of parenteral lipids have improved morbidity and mortality from PNALD in infants with intestinal failure. Current strategies for the treatment of PNALD include restricting the dose of parenteral soybean oil lipid emulsion and/or replacing the soybean oil with a parenteral fish-oil lipid emulsion or emulsions of mixed-lipid sources. The purpose of this report is to review published data that evaluate these strategies in parenteral lipid management for the treatment and prevention of PNALD.
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