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AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
卷 18, 期 1, 页码 139-145出版社
ADIS INT LTD
DOI: 10.1007/s40257-016-0242-0
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Dapsone 7.5% gel (Aczone (R)) is indicated for the once-daily topical treatment of acne vulgaris in patients aged >= 12 years. Dapsone is a sulfone antibacterial with anti-inflammatory actions, which are thought to be largely responsible for its efficacy in treating acne vulgaris. In two phase III trials of 12 weeks' duration in patients aged >= 12 years with moderate acne vulgaris, once-daily dapsone 7.5% gel reduced acne severity (as per the Global Acne Assessment Score) and lesion counts versus vehicle. The benefits of dapsone 7.5% gel over vehicle were seen as early as week 2 for inflammatory lesion counts, and from week 4 or 8 for other outcomes. Dapsone 7.5% gel was well tolerated, with a low incidence of treatment-related adverse events, with the majority of adverse events being administration-site related and mild or moderate in severity. Thus, dapsone 7.5% gel is an effective and well tolerated option for the topical treatment of acne vulgaris in patients aged >= 12 years, with the convenience of once-daily application.
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