期刊
BIOINFORMATICS
卷 32, 期 8, 页码 1185-1194出版社
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btv712
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资金
- Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Energy Sciences, Office of Science, U.S. Department of Energy [DEFG02-91ER20021]
- Natural Science Foundation of China [61173085]
- National High-Tech Research and Development Program (863) of China [2012AA020404, 2012AA02A602, 2012AA02A604, 2014AA021505]
Motivation: Gene ontology (GO) is a widely used resource to describe the attributes for gene products. However, automatic GO maintenance remains to be difficult because of the complex logical reasoning and the need of biological knowledge that are not explicitly represented in the GO. The existing studies either construct whole GO based on network data or only infer the relations between existing GO terms. None is purposed to add new terms automatically to the existing GO. Results: We proposed a new algorithm 'GOExtender' to efficiently identify all the connected gene pairs labeled by the same parent GO terms. GOExtender is used to predict new GO terms with biological network data, and connect them to the existing GO. Evaluation tests on biological process and cellular component categories of different GO releases showed that GOExtender can extend new GO terms automatically based on the biological network. Furthermore, we applied GOExtender to the recent release of GO and discovered new GO terms with strong support from literature.
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