期刊
ALZHEIMERS & DEMENTIA
卷 12, 期 2, 页码 195-202出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2015.05.017
关键词
Dementia; FTD; Alzheimer's disease; MCI; MBI; Neuropsychiatric symptoms of dementia; NPS; Behavior; Behaviour; Agitation; Psychosis; Disinhibition; Apathy; Depression; BPSD
资金
- Veterans Health Administration [BX000452]
- NIH [MH071533, AG05133, AG027224, P50AG005146]
- Department of Veterans Affairs
Neuropsychiatric symptoms (NPS) are common in dementia and in predementia syndromes such as mild cognitive impairment (MCI). NPS in MCI confer a greater risk for conversion to dementia in comparison to MCI patients without NPS. NPS in older adults with normal cognition also confers a greater risk of cognitive decline in comparison to older adults without NPS. Mild behavioral impairment (MBI) has been proposed as a diagnostic construct aimed to identify patients with an increased risk of developing dementia, but who may or may not have cognitive symptoms. We propose criteria that include MCI in the MBI framework, in contrast to prior definitions of MBI. Although MBI and MCI can co-occur, we suggest that they are different and that both portend a higher risk of dementia. These MBI criteria extend the previous literature in this area and will serve as a template for validation of the MBI construct from epidemiologic, neurobiological, treatment, and prevention perspectives. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据