期刊
ALZHEIMERS & DEMENTIA
卷 12, 期 2, 页码 164-169出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2015.07.492
关键词
Alzheimer's disease; Neuropathology; Methods; Whole-slide imaging; Multisite
资金
- National Institute on Aging, National Institutes of Health: National Alzheimer's Coordinating Center [U01 AG016976]
- National Institute on Aging, National Institutes of Health: Alzheimer's Disease Centers [P50 AG05133, P50 AG05134, P50 AG05136, P50 AG05681, P30 AG10161, P30 AG10124, P30 AG13854, P50 AG16570, P30 AG19610, P30 AG28383, P01 AG03991]
Introduction: Neuropathologic assessment is the current gold standard for evaluating the Alzheimer's disease (AD), but there is no consensus on the methods used. Methods: Fifteen unstained slides (8 brain regions) from each of the 14 cases were prepared and distributed to 10 different National Institute on Aging AD Centers for application of usual staining and evaluation following recently revised guidelines for AD neuropathologic change. Results: Current practice used in the AD Centers Program achieved robustly excellent agreement for the severity score for AD neuropathologic change (average weighted kappa = .88, 95% confidence interval: 0.77-0.95) and good-to-excellent agreement for the three supporting scores. Some improvement was observed with consensus evaluation but not with central staining of slides. Evaluation of glass slides and digitally prepared whole-slide images was comparable. Discussion: AD neuropathologic evaluation as performed across AD Centers yields data that have high agreement with potential modifications for modest improvements. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据