期刊
ALZHEIMERS & DEMENTIA
卷 12, 期 5, 页码 604-613出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2015.10.006
关键词
Cohort studies; Alzheimer's disease; Dementia; Benzodiazepine; Psychotropic medication
资金
- Fondation Plan Alzheimer
- Caisse Nationale Maladie des Travailleurs Salaries
- Direction Generale de la Sante
- MGEN
- Institut de la Longevite
- Conseils Regionaux of Aquitaine and Bourgogne
- Fondation de France
- Ministry of Research-INSERM Programme Cohortes et collections de donnees biologiques
- Fondation pour la Recherche Medicale
Introduction: Benzodiazepine use has been associated with increased risk of dementia. However, it remains unclear whether the risk relates to short or long half-life benzodiazepines and whether it extends to other psychotropic drugs. Methods: Prospective cohort study among 8240 individuals >= 65, interviewed on medication use. Incident dementia confirmed by an end point committee after a multistep procedure. Results: During a mean of 8 years of follow-up, 830 incident dementia cases were observed. Users of benzodiazepines at baseline had a 10% increased risk of dementia (adjusted hazard ratio [HR], 1.10; 95% confidence interval, 0.90-1.34). However, long half-life (>20 hours) benzodiazepine users had a marked increased risk of dementia (HR = 1.62; 1.11-2.37) compared with short half-life users (HR = 1.05; 0.85-1.30). Users of psychotropics had an increased risk of dementia (HR = 1.47; 1.16-1.86). Discussion: Results of this large, prospective study show increased risk of dementia for long half-life benzodiazepine and psychotropic use. (C) 2015 Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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