期刊
ALZHEIMERS & DEMENTIA
卷 12, 期 2, 页码 154-163出版社
WILEY
DOI: 10.1016/j.jalz.2015.08.003
关键词
Lumbar puncture; Cognitive disorders; Alzheimer's disease; Memory clinic; Post-LP complications; Post-LP headache; Multicenter study on LP feasibility
资金
- JPND: ZonMw, the Netherlands [629000002]
- Alzheimer's Association USA [170804]
- Swedish Research Council [14002]
- Swedish State Support for Clinical Research
- Alzheimer Nederland [WE.15-2013-08]
- UAntwerp Research Fund
- Alzheimer Research Foundation (SAO-FRA)
- Research Foundation Flanders (FWO)
- Agency for Innovation by Science and Technology (IWT)
- Belgian Science Policy Office Interuniversity Attraction Poles (IAP) program
- Flemish Government initiated Methusalem excellence grant, Belgium
- Instituto de Salud Carlos III, Spain [PI11/02425, PI11/00234, PI11/03035]
- project FNUSA-ICRC from the European Regional Development Fund [CZ.1.05/1.1.00/02.0123]
- MH CZ-DRO, University Hospital Motol, Prague, Czech Republic [00064203]
- Fondo de Investigacion Sanitario, Spain [PI3035]
- FAPESP, Spain [2009/52825-8]
- SAIOTEK program, Government of the Basque Country [S-PR13ZH001]
- Instituto Carlos III, Spain [PI112-02262]
Introduction: Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations. Methods: We prospectively enrolled 3868 patients (50% women, age 66 +/- 11 years, mini mental state examination 25 +/- 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain. Results: A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect. Discussions: The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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