期刊
ALLERGY
卷 72, 期 5, 页码 682-690出版社
WILEY
DOI: 10.1111/all.13089
关键词
asthma; atopic dermatitis; chemokine; chemokine receptor; food allergy
资金
- 'Societe Francaise d'Allergologie'
- 'Fondation pour la recherche Medicale'
- 'La fondation du souffle'
- 'Institut de Recherche en Sante Respiratoire'
- 'Ministere de la Recherche'
- University of Nantes
- The People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7) under REA [624910]
Under homeostatic conditions, as well as in various diseases, leukocyte migration is a crucial issue for the immune system that is mainly organized through the activation of bone marrow-derived cells in various tissues. Immune cell trafficking is orchestrated by a family of small proteins called chemokines. Leukocytes express cell-surface receptors that bind to chemokines and trigger transendothelial migration. Most allergic diseases, such as asthma, rhinitis, food allergies, and atopic dermatitis, are generally classified by the tissue rather than the type of inflammation, making the chemokine/chemokine receptor system a key point of the immune response. Moreover, because small antagonists can easily block such receptors, various molecules have been developed to suppress the recruitment of immune cells during allergic reactions, representing potential new drugs for allergies. We review the chemokines and chemokine receptors that are important in asthma, food allergies, and atopic dermatitis and their respectively developed antagonists.
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