期刊
ALLERGY
卷 72, 期 3, 页码 331-341出版社
WILEY
DOI: 10.1111/all.13051
关键词
asthma; autoimmunity; glucocorticoid resistance; glucocorticoids; Th17 cells
资金
- National Institute of Allergy and Infectious Diseases [R21AI113935]
- National Heart, Lung, and Blood Institute [R37HL068546]
- Bazley Foundation
Th17 cells contribute to several inflammatory conditions and increasing evidence supports that Th17 cells are glucocorticoid resistant. However, Th17 cells in psoriasis and related diseases are glucocorticoid sensitive. We compare glucocorticoid sensitive and resistant immunological diseases and suggest that several aspects in Th17-related diseases alter glucocorticoid sensitivity of Th17 cells. We identify molecular pathways that are implicated in glucocorticoid sensitivity of Th17 cells in the literature, as this information is useful for developing approaches to overcome glucocorticoid-resistant immunopathology.
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