期刊
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
卷 40, 期 10, 页码 2085-2093出版社
WILEY-BLACKWELL
DOI: 10.1111/acer.13197
关键词
Alcohol; Sex; Heavy Drinking Markers; Fatty Acids; Liver Injury
资金
- Intramural NIH HHS [Z99 AA999999, ZIA AA000213, ZIA AA000466] Funding Source: Medline
- NIAAA NIH HHS [U01 AA021901, P50 AA024337, R01 AA023681] Funding Source: Medline
- NIGMS NIH HHS [P20 GM113226] Funding Source: Medline
- BLRD VA [I01 BX002996] Funding Source: Medline
BackgroundHeavy alcohol consumption frequently causes liver inflammation/injury, and certain fatty acids (FAs) may be involved in this liver pathology. In this study, we evaluated the association of heavy drinking and the changes in the FA levels involved in the -6 (pro-inflammatory) and -3 (anti-inflammatory) state in alcohol-dependent (AD) patients who had no clinical manifestations of liver injury. We aimed to identify sex-based differences in patients with mild or no biochemical evidence of liver injury induced by heavy drinking. MethodsA total of 114 heavy drinking AD female and male patients aged 21 to 65years without clinical manifestations of liver injury, who were admitted to an alcohol dependence treatment program, were grouped by the alanine aminotransferase (ALT) levels: 40 IU/l, as no liver injury (GR.1), and >40 IU/l, as mild liver injury (GR.2). Patients were actively drinking until the day of admission. Comprehensive metabolic panel, comprehensive FA panel, and drinking history data were evaluated. ResultsElevated ALT and aspartate aminotransferase (AST) showed close association with markers of heavy alcohol intake. In the patients with mild biochemical liver injury (GR.2), females showed significantly higher AST level than males. Significant association of AST and total drinks in past 90 days (TD90) in females, and AST and heavy drinking days in past 90 days (HDD90) in males was observed. The -6:-3 ratio showed a significant pro-inflammatory response only in females with mild liver injury (GR.2) when adjusted by drinking history marker, TD90. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were increased in males with liver injury, while females did not show any comparable rise in EPA; and DHA levels were lower. ConclusionsMeasures of heavy drinking, TD90 and HDD90, predicted changes in liver injury. Changes in the -3 and -6 FA levels and the -6:-3 ratio showed a pro-inflammatory shift in patients with biochemical liver injury with a significant effect in females. Changes in FAs involved in the inflammatory state may represent one mechanism for liver inflammation/injury in response to heavy alcohol drinking.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据