4.4 Article

Elevated levels of invariant natural killer T-cell and natural killer cell activation correlate with disease progression in HIV-1 and HIV-2 infections

期刊

AIDS
卷 30, 期 11, 页码 1713-1722

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0000000000001147

关键词

CD38; HIV-1; HIV-2; immune activation; invariant natural killer T cells; natural killer cells; viremia

资金

  1. Swedish Research Council
  2. Swedish Cancer Society
  3. Stockholm County Council
  4. Karolinska Institutet
  5. Crafoord Foundation
  6. US National Institutes of Health [AI52731]

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Objective: In this study, we aimed to investigate the frequency and activation of invariant natural killer T (iNKT) cells and natural killer (NK) cells among HIV-1, HIV-2, or dually HIV-1/HIV-2 (HIV-D)-infected individuals, in relation to markers of disease progression. Design: Whole blood samples were collected from treatment-naive HIV-1 (n = 23), HIV-2 (n = 34), and HIV-D (n = 11) infected individuals, as well as HIV-seronegative controls (n = 25), belonging to an occupational cohort in Guinea-Bissau. Methods: Frequencies and activation levels of iNKT and NK cell subsets were analysed using multicolour flow cytometry, and results were related to HIV-status, CD4(+) T-cell levels, viral load, and T-cell activation. Results: HIV-1, HIV-D, and viremic HIV-2 individuals had lower numbers of CD4(+) iNKT cells in circulation compared with seronegative controls. Numbers of CD56(bright) NK cells were also reduced in HIV-infected individuals as compared with control study participants. Notably, iNKT cell and NK cell activation levels, assessed by CD38 expression, were increased in HIV-1 and HIV-2 single, as well as dual, infections. HIV-2 viremia was associated with elevated activation levels in CD4(+) iNKT cells, CD56(bright), and CD56(dim) NK cells, as compared with aviremic HIV-2 infection. Additionally, disease markers such as CD4(+) T-cell percentages, viral load, and CD4(+) T-cell activation were associated with CD38 expression levels of both iNKT and NK cells, which activation levels also correlated with each other. Conclusion: Our data indicate that elevated levels of iNKT-cell and NK-cell activation are associated with viremia and disease progression markers in both HIV-1 and HIV-2 infections. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

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