期刊
AICHE JOURNAL
卷 63, 期 3, 页码 967-974出版社
WILEY
DOI: 10.1002/aic.15438
关键词
reactive crystallization; continuous crystallization; continuous processing of pharmaceuticals; impinging jet mixer; process analytical technology; sodium cefuroxime
资金
- UK Engineering and Physical Sciences Research Council [EP/H008012/1, EP/H008853/1]
- China Scholarship Council (CSC)
- China Thousand Talents Scheme
- National Natural Science Foundation of China (NNSFC) under its Major Research Scheme of Meso-scale Mechanism and Control in Multi-phase Reaction Processes [91434126]
- Natural Science Foundation of Guangdong Province [2014A030313228]
- Guangdong Provincial Science and Technology Projects under the Scheme of Applied Science and Technology Research Special Funds [2015B020232007]
- EPSRC [EP/H008012/1, EP/H008853/1, EP/E040624/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/H008012/1, EP/H008853/1, EP/E040624/1] Funding Source: researchfish
For reactive crystallization of pharmaceuticals that show a rapid reaction rate, low solubility of active pharmaceutical ingredient and hence a large supersaturation, it was found in a recent study that a process design which integrates an impinging jet mixer and batch stirred tank produces high quality crystals. The current investigation examines if the short processing time of reactive crystallization permits the impinging jet mixerstirred tank design to be modified to operate in a continuous mode. The new design combines an impinging jet mixer for feed introduction and reaction with a continuous stirred tank reactor (CSTR) and tubular reactor for crystal growth. A study of reactive crystallization of sodium cefuroxime (an antibiotic), using first a 1L CSTR then scaling to a 50L CSTR, found that the new design produces crystals of higher crystallinity, narrower particle size, and improved product stability, than batch crystallizers. (c) 2016 American Institute of Chemical Engineers AIChE J, 63: 967-974, 2017
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