期刊
BIOESSAYS
卷 37, 期 5, 页码 479-488出版社
WILEY
DOI: 10.1002/bies.201400174
关键词
epigenome; evolution; genome reshuffling; nucleome; recombination; selection
资金
- BBSRC [BB/J010170/1]
- South African National Research Foundation
- Spanish Ministerio de Ciencia y Tecnologia [CGL-2010-20170]
- BBSRC [BB/J010170/2, BB/J010170/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/J010170/2, BB/J010170/1] Funding Source: researchfish
Our understanding of genomic reorganization, the mechanics of genomic transmission to offspring during germ line formation, and how these structural changes contribute to the speciation process, and genetic disease is far from complete. Earlier attempts to understand the mechanism(s) and constraints that govern genome remodeling suffered from being too narrowly focused, and failed to provide a unified and encompassing view of how genomes are organized and regulated inside cells. Here, we propose a new multidisciplinary Integrative Breakage Model for the study of genome evolution. The analysis of the high-level structural organization of genomes (nucleome), together with the functional constrains that accompany genome reshuffling, provide insights into the origin and plasticity of genome organization that may assist with the detection and isolation of therapeutic targets for the treatment of complex human disorders.
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