期刊
BIOESSAYS
卷 37, 期 12, 页码 1327-1337出版社
WILEY
DOI: 10.1002/bies.201500055
关键词
adaptive immunity; carbohydrates; galectins; innate immunity; lectins; microbes
资金
- National Blood Foundation
- Hemophilia of Georgia
- Burroughs Wellcome Trust Career Award for Medical Scientists
- National Institutes of Health grant [DP5OD019892]
Adaptive immunity provides the unique ability to respond to a nearly infinite range of antigenic determinants. Given the inherent plasticity of the adaptive immune system, a series of tolerance mechanisms exist to reduce reactivity toward self. While this reduces the probability of autoimmunity, it also creates an important gap in adaptive immunity: the ability to recognize microbes that look like self. As a variety of microbes decorate themselves in self-like carbohydrate antigens and tolerance reduces the ability of adaptive immunity to react with self-like structures, protection against molecular mimicry likely resides within the innate arm of immunity. In this review, we will explore the potential consequences of microbial molecular mimicry, including factors within innate immunity that appear to specifically target microbes expressing self-like antigens, and therefore provide protection against molecular mimicry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据