期刊
BIOESSAYS
卷 37, 期 8, 页码 851-856出版社
WILEY-BLACKWELL
DOI: 10.1002/bies.201400205
关键词
dynamic regulation; gene regulatory networks; Hit-and-Run; TF binding; transcriptional model; transcriptional regulation
资金
- NIH [RO1-GM032877]
- NSF [MCB-0929338]
- NIH NRSA [GM095273]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [F32GM095273, R01GM032877] Funding Source: NIH RePORTER
- Div Of Molecular and Cellular Bioscience [1412232] Funding Source: National Science Foundation
Understanding how transcription factor (TF) binding is related to gene regulation is a moving target. We recently uncovered genome-wide evidence for a Hit-and-Run model of transcription. In this model, a master TF hits a target promoter to initiate a rapid response to a signal. As the hit is transient, the model invokes recruitment of partner TFs to sustain transcription over time. Following the run, the master TF hits other targets to propagate the response genome-wide. As such, a TF may act as a catalyst to mount a broad and acute response in cells that first sense the signal, while the recruited TF partners promote long-term adaptive behavior in the whole organism. This Hit-and-Run model likely has broad relevance, as TF perturbation studies across eukaryotes show small overlaps between TF-regulated and TF-bound genes, implicating transient TF-target binding. Here, we explore this Hit-and-Run model to suggest molecular mechanisms and its biological relevance.
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