期刊
BIOESSAYS
卷 37, 期 9, 页码 959-967出版社
WILEY-BLACKWELL
DOI: 10.1002/bies.201500041
关键词
cytokine; dimerization; ligand binding; preformed dimer; transmembrane signaling; tyrosine kinase
资金
- Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
It has long been thought that transmembrane cell-surface receptors, such as receptor tyrosine kinases and cytokine receptors, among others, are activated by ligand binding through ligand-induced dimerization of the receptors. However, there is growing evidence that prior to ligand binding, various transmembrane receptors have a preformed, yet inactive, dimeric structure on the cell surface. Various studies also demonstrate that during transmembrane signaling, ligand binding to the extracellular domain of receptor dimers induces a rotation of transmembrane domains, followed by rearrangement and/or activation of intracellular domains. The paper here describes transmembrane cell-surface receptors that are known or proposed to exist in dimeric form prior to ligand binding, and discusses how these preformed dimers are activated by ligand binding.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据