期刊
AGING-US
卷 8, 期 1, 页码 111-126出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100877
关键词
lifestyle intervention; older adults; caloric restriction; physical activity; metabolic health; healthy ageing
资金
- European Union [259679]
- Netherlands Consortium for Healthy Ageing, Netherlands Genomics Initiative, Netherlands Organization for Scientific Research (NWO) [050-060-810]
- BBMRI-NL, a Research Infrastructure - Dutch government [NWO 184.021.007]
- Netherlands CardioVascular Research Initiative [CVON201-03]
For people in their 40s and 50s, lifestyle programs have been shown to improve metabolic health. For older adults, however, it is not clear whether these programs are equally healthy. In the Growing Old Together study, we applied a 13-weeks lifestyle program, with a target of 12.5% caloric restriction and 12.5% increase in energy expenditure through an increase in physical activity, in 164 older adults ( mean age=63.2 years; BMI=23-35 kg/m(2)). Mean weight loss was 4.2% (SE=2.8%) of baseline weight, which is comparable to a previous study in younger adults. Fasting insulin levels, however, showed a much smaller decrease (0.30 mU/L (SE=3.21)) and a more heterogeneous response (range=2.0-29.6 mU/L). Many other parameters of metabolic health, such as blood pressure, and thyroid, glucose and lipid metabolism improved significantly. Many H-1-NMR metabolites changed in a direction previously associated with a low risk of type 2 diabetes and cardiovascular disease and partially independently of weight loss. In conclusion, 25% reduction in energy balance for 13 weeks induced a metabolic health benefit in older adults, monitored by traditional and novel metabolic markers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据