期刊
AGING-US
卷 8, 期 1, 页码 3-11出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100871
关键词
cellular senescence; telomere; replicative senescence; aging; biomarkers; telomere theory
资金
- Russian Foundation for Basic Research [14-15-00943]
- Russian Science Foundation [14-15-00943] Funding Source: Russian Science Foundation
The cellular senescence definition comes to the fact of cells irreversible proliferation disability. Besides the cell cycle arrest, senescent cells go through some morphological, biochemical, and functional changes which are the signs of cellular senescence. The senescent cells (including replicative senescence and stress-induced premature senescence) of all the tissues look alike. They are metabolically active and possess the set of characteristics in vitro and in vivo, which are known as biomarkers of aging and cellular senescence. Among biomarkers of cellular senescence telomere shortening is a rather elegant frequently used biomarker. Validity of telomere shortening as a marker for cellular senescence is based on theoretical and experimental data.
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