期刊
AGEING RESEARCH REVIEWS
卷 30, 期 -, 页码 61-72出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2016.02.006
关键词
Functional neuroimaging; fMRI; Aging; Cognitive decline; Adaptation
资金
- Topic-Setting Program to Advance Cutting-Edge Humanities and Social Sciences Research (Area Cultivation)
- KAKENHI from JSPS [25560347]
- Grants-in-Aid for Scientific Research [25560347] Funding Source: KAKEN
Early functional neuroimaging research on normal aging brain has been dominated by the interest in cognitive decline. In this framework the age-related compensatory recruitment of prefrontal cortex, in terms of executive system or reduced lateralization, has been established. Further details on these compensatory mechanisms and the findings reflecting cognitive decline, however, remain the matter of intensive investigations. Studies in another framework where age-related neural alteration is considered adaptation to the environmental change are recently burgeoning and appear largely categorized into three domains. The age-related increase in activation of the sensorimotor network may reflect the alteration of the peripheral sensorimotor systems. The increased susceptibility of the network for the mental-state inference to the socioemotional significance may be explained by the age-related motivational shift due to the altered social perception. The age-related change in activation of the self-referential network may be relevant to the focused positive self-concept of elderly driven by a similar motivational shift. Across the domains, the concept of the self and internal model may provide the theoretical bases of this adaptation framework. These two frameworks complement each other to provide a comprehensive view of the normal aging brain. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据