期刊
AGEING RESEARCH REVIEWS
卷 26, 期 -, 页码 112-114出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2016.01.006
关键词
Alzheimer's disease; Animal models; Non-human primates
资金
- National Institute for Translational Neuroscience (INNT/Brazil)
- Brazilian funding agency Conselho Nacional de DesenvolvimentoCientifico e Tecnologico (CNPq)
- Brazilian funding agency Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- Canadian Institutes for Health Research (CIHR) [MOP-38854]
- Canada Research Chair Program
A major impediment to the development of safe and effective therapeutics in Alzheimer's disease (AD) lies in difficulties in translating research findings across species: therapies that work in rodents often do not translate to humans. A route to bridge the gap between promising rodent research and the human clinical condition consists in using non-human primates (NHPs), which are phylogenetically much closer to humans. In this article, we discuss the importance of investigating disease mechanisms from cell culture, through different animal models of disease. We highlight that developing a viable, validated NHP AD model will likely be a key step toward understanding AD-relevant pathogenic mechanisms and for developing therapies that will effectively translate to the human disease condition. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据