期刊
AGEING RESEARCH REVIEWS
卷 30, 期 -, 页码 107-113出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2015.12.010
关键词
Tau proteins; Neurofibrillary tangles; Positron emission tomography; Neuroimaging; Alzheimer's disease
资金
- GE Healthcare
- SEI (Sumitomo Electric Industries, Ltd.) Group
- CSR Foundation
- Health and Labor Sciences research grants from the Ministry of Health, Labor, and Welfare of Japan
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [15H04900, 26117003]
- Grants-in-Aid for Scientific Research [15H04900] Funding Source: KAKEN
Alzheimer's disease and other neurodegenerative dementias belong to the family of tauopathies. These diseases are characterized by the deposition of insoluble tau aggregates possessing an enriched beta-sheet structure. In vivo imaging of the tau deposits by positron emission tomography (PET) will facilitate the early and accurate diagnosis of these diseases, tracking of disease progression, assessment of disease severity, and prediction of disease prognosis. Furthermore, this technology is expected to play a vital role in the monitoring of treatment outcomes and in the selection of patients for the therapeutic trials of anti-dementia drugs. Recently, several tau PET tracers have been successfully developed and demonstrated as having high binding affinity and selectivity to tau protein deposits. Recent clinical studies using these tracers have demonstrated significant tracer retention in sites susceptible to tau deposition in Alzheimer's disease, as well as correlations with the disease severity and cognitive impairment in cases with dementia. These tracers, thus, have the potential to effectively diagnose the tauopathies. Further longitudinal assessment will clarify the effect of the tau deposition on the neurodegenerative process and cognitive decline and the interaction of tau with amyloid-beta in the human brain. (C) 2016 Elsevier B.V. All rights reserved.
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