期刊
AGEING RESEARCH REVIEWS
卷 32, 期 -, 页码 140-149出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2016.02.008
关键词
Parkinson's disease; Lysosomes; Neurodegeneration; Therapeutic
资金
- Marie Curie Reintegration Grant from the European Commission [FP7-PEOPLE-2009-ERG256303]
- PEPS-Idex [1024R-3219]
- Fondation pour la Recherche Medicale
- MESR fellowship
- France Parkinson Foundation
Parkinson's disease is a common neurodegenerative disorder of unknown origin mainly characterized by the loss of neuromelanin-containing dopaminergic neurons in the substantia nigra pars compacta and the presence of intraneuronal proteinaceous inclusions called Lewy bodies. Lysosomes are dynamic organelles that degrade, in a controlled manner, cellular components delivered via the secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Increasing amounts of evidence suggest a central role of lysosomal impairment in PD aetiology. This review provides an update on how genetic evidence support this connection and highlights how the neuropathologic and mechanistic evidence might relate to the disease process in sporadic forms of Parkinson's disease. Finally, we discuss the influence of ageing on lysosomal impairment and PD aetiology and therapeutic strategies targeting lysosomal function. (C) 2016 Elsevier B.V. All rights reserved.
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