相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Different Expression Patterns of Amyloid-beta Protein Precursor Secretases in Human and Mouse Hippocampal Neurons: A Potential Contribution to Species Differences in Neuronal Susceptibility to Amyloid-beta Pathogenesis
Zhi-Qiang Xu et al.
JOURNAL OF ALZHEIMERS DISEASE (2016)
Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease
Lana M. Osborn et al.
PROGRESS IN NEUROBIOLOGY (2016)
Neuroimaging of hippocampal atrophy in early recognition of Alzheimer's disease - a critical appraisal after two decades of research
Johannes Schroeder et al.
PSYCHIATRY RESEARCH-NEUROIMAGING (2016)
Characterization of Social Behaviors in caspase-3 deficient mice
Shih-Ching Lo et al.
SCIENTIFIC REPORTS (2016)
Sigma-2 receptor binding is decreased in female, but not male, APP/PS1 mice
Kristoffer Sahlholm et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
4Aβ1-15-Derived Monoclonal Antibody Reduces More Aβ Burdens and Neuroinflammation than Homologous Vaccine in APP/PS1 Mice
Yuwei Zhang et al.
CURRENT ALZHEIMER RESEARCH (2015)
Isolation Housing Exacerbates Alzheimer's Disease-Like Pathophysiology in Aged APP/PS1 Mice
Huang Huang et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2015)
Arginase 1+microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation
Jonathan D. Cherry et al.
JOURNAL OF NEUROINFLAMMATION (2015)
Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits
Zhiqiang Xu et al.
MOLECULAR NEURODEGENERATION (2015)
Clearance systems in the brain-implications for Alzheimer disease
Jenna M. Tarasoff-Conway et al.
NATURE REVIEWS NEUROLOGY (2015)
Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice
Daijiro Yanagisawa et al.
NEUROBIOLOGY OF AGING (2015)
Behavioral abnormalities in APPSwe/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains
Christopher Janus et al.
NEUROBIOLOGY OF AGING (2015)
Genetics and Underlying Pathology of Dementia
Beata Ferencz et al.
NEUROPSYCHOLOGY REVIEW (2015)
DONEPEZIL IMPROVES LEARNING AND MEMORY DEFICITS IN APP/PS1 MICE BY INHIBITION OF MICROGLIAL ACTIVATION
H. B. Guo et al.
NEUROSCIENCE (2015)
Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease
Siddhita D. Mhatre et al.
TRENDS IN NEUROSCIENCES (2015)
The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease
Josiane Budni et al.
AGING AND DISEASE (2015)
FIBT versus florbetaben and PiB: a preclinical comparison study with amyloid-PET in transgenic mice
Behrooz H. Yousefi et al.
EJNMMI RESEARCH (2015)
Microglia as a critical player in both developmental and late-life CNS pathologies
Noel C. Derecki et al.
ACTA NEUROPATHOLOGICA (2014)
Potassium 2-(1-hydroxypentyl)-benzoate promotes long-term potentiation in Aβ1-42-injected rats and APP/PS1 transgenic mice
Ping-ping Li et al.
ACTA PHARMACOLOGICA SINICA (2014)
Risk Factors for Behavioral Abnormalities in Mild Cognitive Impairment and Mild Alzheimer's Disease
Liana G. Apostolova et al.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2014)
Neuronal and Glial Alterations, Increased Anxiety, and Cognitive Impairment Before Hippocampal Amyloid Deposition in PDAPP Mice, Model of Alzheimer's Disease
Juan Beauquis et al.
HIPPOCAMPUS (2014)
Resveratrol increases cerebral glycogen synthase kinase phosphorylation as well as protein levels of drebrin and transthyretin in mice: an exploratory study
Behzad Varamini et al.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2014)
Social Interaction Rescues Memory Deficit in an Animal Model of Alzheimer's Disease by Increasing BDNF-Dependent Hippocampal Neurogenesis
Ya-Hsin Hsiao et al.
JOURNAL OF NEUROSCIENCE (2014)
Multimodality Imaging of Alzheimer Disease and Other Neurodegenerative Dementias
Ilya M. Nasrallah et al.
JOURNAL OF NUCLEAR MEDICINE (2014)
Association of type 2 diabetes with brain atrophy and cognitive impairment
Rosebud O. Roberts et al.
NEUROLOGY (2014)
Altered cerebral vascular volumes and solute transport at the blood-brain barriers of two transgenic mouse models of Alzheimer's disease
Tuan Minh Do et al.
NEUROPHARMACOLOGY (2014)
Genetic mouse models of brain ageing and Alzheimer's disease
Andras Bilkei-Gorzo
PHARMACOLOGY & THERAPEUTICS (2014)
Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase
Maho Morishima-Kawashima
FRONTIERS IN PHYSIOLOGY (2014)
Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
Scott J. Webster et al.
FRONTIERS IN GENETICS (2014)
Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models
Michal Arbel-Ornath et al.
ACTA NEUROPATHOLOGICA (2013)
Voluntary exercise counteracts Aβ25-35-induced memory impairment in mice
Qin Wang et al.
BEHAVIOURAL BRAIN RESEARCH (2013)
Epidemiology and Etiology of Alzheimer’s disease: From Genetic to Non- Genetic Factors
Teng Jiang et al.
Current Alzheimer Research (2013)
A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice
Varsha Shukla et al.
FASEB JOURNAL (2013)
Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis
Zhi-Yuan Zhang et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2013)
Intracranial Injection of Gammagard, a Human IVIg, Modulates the Inflammatory Response of the Brain and Lowers Aβ in APP/PS1 Mice Along a Different Time Course than Anti-Aβ Antibodies
Tiffany L. Sudduth et al.
JOURNAL OF NEUROSCIENCE (2013)
Ushering in the study and treatment of preclinical Alzheimer disease
Jessica B. Langbaum et al.
NATURE REVIEWS NEUROLOGY (2013)
Long-term social isolation in the adulthood results in CM shrinkage and cognitive impairment
Inmaculada Pereda-Perez et al.
NEUROBIOLOGY OF LEARNING AND MEMORY (2013)
THE INCRETIN ANALOGUE D-ALA2GIP REDUCES PLAQUE LOAD, ASTROGLIOSIS AND OXIDATIVE STRESS IN AN APP/PS1 MOUSE MODEL OF ALZHEIMER'S DISEASE
A. M. Duffy et al.
NEUROSCIENCE (2013)
The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer's Disease
Tomi Rantamaki et al.
PLOS ONE (2013)
GDNF, NGF and BDNF as therapeutic options for neurodegeneration
Shelley J. Allen et al.
PHARMACOLOGY & THERAPEUTICS (2013)
Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment
I. H. G. B. Ramakers et al.
PSYCHOLOGICAL MEDICINE (2013)
Sleep Drives Metabolite Clearance from the Adult Brain
Lulu Xie et al.
SCIENCE (2013)
Increased in Vivo Amyloid-β42 Production, Exchange, and Loss in Presenilin Mutation Carriers
Rachel Potter et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease
Scott J. Webster et al.
ALZHEIMERS RESEARCH & THERAPY (2013)
Immunocytochemical Characterization of Alzheimer Disease Hallmarks in APP/PS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine
Ivan Carrera et al.
BIOMED RESEARCH INTERNATIONAL (2013)
Age and Rate of Cognitive Decline in Alzheimer Disease Implications for Clinical Trials
Charles Bernick et al.
ARCHIVES OF NEUROLOGY (2012)
Sensorimotor gating and memory deficits in an APP/PS1 double transgenic mouse model of Alzheimer's disease
Hongxing Wang et al.
BEHAVIOURAL BRAIN RESEARCH (2012)
Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)
Mohammed Filali et al.
BEHAVIOURAL BRAIN RESEARCH (2012)
Alzheimer Mechanisms and Therapeutic Strategies
Yadong Huang et al.
CELL (2012)
Astrocytes: more than just glue
Peter Baxter
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY (2012)
The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: an update
Kelly R. Bales
EXPERT OPINION ON DRUG DISCOVERY (2012)
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimers disease
Maria Manczak et al.
HUMAN MOLECULAR GENETICS (2012)
Recent rodent models for Alzheimer's disease: clinical implications and basic research
Nady Braidy et al.
JOURNAL OF NEURAL TRANSMISSION (2012)
High throughput object-based image analysis of β-amyloid plaques in human and transgenic mouse brain
Harry D. Samaroo et al.
JOURNAL OF NEUROSCIENCE METHODS (2012)
Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG
Stephen F. Carter et al.
JOURNAL OF NUCLEAR MEDICINE (2012)
Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice
Liam Scott et al.
NEUROBIOLOGY OF AGING (2012)
Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
Simon Gengler et al.
NEUROBIOLOGY OF AGING (2012)
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
Jeffrey J. Iliff et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation
Demian Obregon et al.
NATURE COMMUNICATIONS (2012)
Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice
Guilian Xu et al.
ALZHEIMERS RESEARCH & THERAPY (2012)
Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation
Hui-li Liu et al.
BEHAVIOURAL BRAIN RESEARCH (2011)
Selective improvement of cognitive function in adult and aged APP/PS1 transgenic mice by continuous non-shock treadmill exercise
Hsing-Chieh Ke et al.
BRAIN RESEARCH (2011)
Potential Predictors of Hippocampal Atrophy in Alzheimer's Disease
Vikas Dhikav et al.
DRUGS & AGING (2011)
Ablation of Cellular Prion Protein Does Not Ameliorate Abnormal Neural Network Activity or Cognitive Dysfunction in the J20 Line of Human Amyloid Precursor Protein Transgenic Mice
Moustapha Cisse et al.
JOURNAL OF NEUROSCIENCE (2011)
AMYLOID Little proteins, big clues
Jim Schnabel
NATURE (2011)
Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease
Mohammed Filali et al.
PHYSIOLOGY & BEHAVIOR (2011)
Alzheimer's Disease: The Challenge of the Second Century
David M. Holtzman et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Identification of Low Molecular Weight Pyroglutamate Aβ Oligomers in Alzheimer Disease A NOVEL TOOL FOR THERAPY AND DIAGNOSIS
Oliver Wirths et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice
James J. Donkin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Many Neuronal and Behavioral Impairments in Transgenic Mouse Models of Alzheimer's Disease Are Independent of Caspase Cleavage of the Amyloid Precursor Protein
Julie A. Harris et al.
JOURNAL OF NEUROSCIENCE (2010)
Brain-Derived Neurotrophic Factor Is Associated with Age-Related Decline in Hippocampal Volume
Kirk I. Erickson et al.
JOURNAL OF NEUROSCIENCE (2010)
Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice
Monica Garcia-Alloza et al.
NEUROBIOLOGY OF AGING (2010)
Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease
Mark Kilgore et al.
NEUROPSYCHOPHARMACOLOGY (2010)
ASTROGLIAL CONNEXIN IMMUNOREACTIVITY IS SPECIFICALLY ALTERED AT β-AMYLOID PLAQUES IN β-AMYLOID PRECURSOR PROTEIN/PRESENILIN1 MICE
X. Mei et al.
NEUROSCIENCE (2010)
MECHANISMS OF DISEASE Alzheimer's Disease
Henry W. Querfurth et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease
Kwasi G. Mawuenyega et al.
SCIENCE (2010)
'Too much good news' - are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?
Kathleen R. Zahs et al.
TRENDS IN NEUROSCIENCES (2010)
Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease
Timothy P. O'Leary et al.
BEHAVIOURAL BRAIN RESEARCH (2009)
A Reporter of Local Dendritic Translocation Shows Plaque-Related Loss of Neural System Function in APP-Transgenic Mice
Melanie Meyer-Luehmann et al.
JOURNAL OF NEUROSCIENCE (2009)
Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer's Disease
Shiyong Peng et al.
JOURNAL OF NEUROSCIENCE (2009)
Morphological alterations to neurons of the amygdala and impaired fear conditioning in a transgenic mouse model of Alzheimer's disease
Shira Knafo et al.
JOURNAL OF PATHOLOGY (2009)
Proteomics-Determined Differences in the Concanavalin-A-Fractionated Proteome of Hippocampus and Inferior Parietal Lobule in Subjects with Alzheimer's Disease and Mild Cognitive Impairment: Implications for Progression of AD
Joshua B. Owen et al.
JOURNAL OF PROTEOME RESEARCH (2009)
NEUROSCIENCE Glia - more than just brain glue
Nicola J. Allen et al.
NATURE (2009)
Multimodal techniques for diagnosis and prognosis of Alzheimer's disease
Richard J. Perrin et al.
NATURE (2009)
Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice
Alexandra Bernardo et al.
NEUROBIOLOGY OF AGING (2009)
Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance
Jungsu Kim et al.
NEURON (2009)
Recent insights into the molecular genetics of dementia
Rosa Rademakers et al.
TRENDS IN NEUROSCIENCES (2009)
Neprilysin: An enzyme candidate to slow the progression of Alzheimer's disease
Salim S. El-Amouri et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
Effects of the genetic background on cognitive performances of TG2576 mice
Jean Michel Lassalle et al.
BEHAVIOURAL BRAIN RESEARCH (2008)
New insights into brain BDNF function in normal aging and Alzheimer disease
Lucia Tapia-Arancibia et al.
BRAIN RESEARCH REVIEWS (2008)
Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice
R. Minkeviciene et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Alzheimer's disease - The latest suspect
Rudolph E. Tanzi et al.
NATURE (2008)
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
Lars Bertram et al.
NATURE REVIEWS NEUROSCIENCE (2008)
Acquisition of conditioned taste aversion is impaired in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease
P. J. Pistell et al.
NEUROSCIENCE (2008)
Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease
Dongfeng Cao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Amyloid beta deposition is related to decreased glucose transporter-1 levels and hippocampal atrophy in brains of aged APP/PS1 mice
Carlijn R. Hooijmans et al.
BRAIN RESEARCH (2007)
Baseline predictors of rates of hippocampal atrophy in mild cognitive impairment
L. A. van de Pol et al.
NEUROLOGY (2007)
The effects of JWB1-84-1 on memory-related task performance by amyloid Aβ transgenic mice and by young and aged monkeys
Ajay Sood et al.
NEUROPHARMACOLOGY (2007)
Hippocampal atrophy correlates with the severity of cognitive decline
Burcu Balam Yavuz et al.
INTERNATIONAL PSYCHOGERIATRICS (2007)
Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice
Rhonda L. Nelson et al.
EXPERIMENTAL NEUROLOGY (2007)
Increase of locomotor activity underlying the behavioral disinhibition in Tg2576 mice
Francisco J. Gil-Bea et al.
BEHAVIORAL NEUROSCIENCE (2007)
Impaired spatial learning in the APPSwe+PSEN1ΔE9 bigenic mouse model of Alzheimer's disease
R. S. Reiserer et al.
GENES BRAIN AND BEHAVIOR (2007)
Subcutaneous Nogo receptor removes brain amyloid-β and improves spatial memory in Alzheimer's transgenic mice
James H. Park et al.
JOURNAL OF NEUROSCIENCE (2006)
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice
M. Oksman et al.
NEUROBIOLOGY OF DISEASE (2006)
Deposition of mouse amyloid β in human APP/PS1 double and single AD model transgenic mice
Thomas van Groen et al.
NEUROBIOLOGY OF DISEASE (2006)
Protective effects of iptakalim, a novel ATP-sensitive potassium channel opener, on global cerebral ischemia-evoked insult in gerbils
Hua Chen et al.
ACTA PHARMACOLOGICA SINICA (2006)
Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment
HM Schipper et al.
NEUROBIOLOGY OF AGING (2006)
Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease:: review and hypothesis
WQ Qiu et al.
NEUROBIOLOGY OF AGING (2006)
Lamina-specific distribution of synaptopodin, an actin-associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampus
CB Orth et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2005)
Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease
SY Peng et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease
JL Jankowsky et al.
JOURNAL OF NEUROSCIENCE (2005)
Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging
DS Wang et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)
Age- and region-dependent alterations in Aβ-degrading enzymes:: implications for Aβ-induced disorders
A Caccamo et al.
NEUROBIOLOGY OF AGING (2005)
Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice
F Trinchese et al.
ANNALS OF NEUROLOGY (2004)
Exploratory activity, anxiety, and motor coordination in bigenic APPswe+PS1/ΔE9 mice
R Lalonde et al.
NEUROSCIENCE LETTERS (2004)
Amyloid-β deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice
M Sadowski et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2004)
Apoptosis of astrocytes with enhanced lysosomal activity and oligodendrocytes in white matter lesions in Alzheimer's disease
K Kobayashi et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2002)
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
JL Jankowsky et al.
BIOMOLECULAR ENGINEERING (2001)
Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes
GW Arendash et al.
BRAIN RESEARCH (2001)
Reduced neprilysin in high plaque areas of Alzheimer brain:: a possible relationship to deficient degradation of β-amyloid peptide
K Yasojima et al.
NEUROSCIENCE LETTERS (2001)
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
D Morgan et al.
NATURE (2000)
分享论文
