期刊
AGE
卷 38, 期 3, 页码 -出版社
SPRINGER
DOI: 10.1007/s11357-016-9927-9
关键词
DNA methylation; DNAmAge; Epigenetic clock; Follow-up; Immunosenescence
资金
- Academy of Finland [286284, 132704, 134309, 126925, 121584, 124282, 129378, 117787, 41071, 250602]
- Social Insurance Institution of Finland
- Kuopio, Tampere and Turku University Hospital Medical Funds [X51001]
- Juho Vainio Foundation
- Paavo Nurmi Foundation
- Finnish Foundation of Cardiovascular Research
- Tampere Tuberculosis Foundation
- Emil Aaltonen Foundation
- Finnish Cultural Foundation
- Pirkanmaa Regional fund
- Yrjo Jahnsson Foundation
- Competitive Research Fund of Pirkanmaa Hospital District [9M017, 9N013, 9P002]
- Sigrid Juselius Foundation
- Finnish Medical Association
- Competitive Research Fund of Fimlab Laboratories [X51409]
The epigenetic clock, defined as the DNA methylome age (DNAmAge), is a candidate biomarker of ageing. In this study, we aimed to characterize the behaviour of this marker during the human lifespan in more detail using two follow-up cohorts (the Young Finns study, calendar age i.e. cAge range at baseline 15-24 years, 25-year-follow-up, N = 183; The Vitality 90+ study, cAge range at baseline 19-90 years, 4-year-follow-up, N = 48). We also aimed to assess the relationship between DNAmAge estimate and the blood cell distributions, as both of these measures are known to change as a function of age. The subjects' DNAmAges were determined using Horvath's calculator of epigenetic cAge. The estimate of the DNA methylome age acceleration (Delta-cAge-DNAmAge) demonstrated remarkable stability in both cohorts: the individual rank orders of the DNAmAges remained largely unchanged during the follow-ups. The blood cell distributions also demonstrated significant intraindividual correlation between the baseline and followup time points. Interestingly, the immunosenescence-associated features (CD8+CD28- and CD4+CD28- cell proportions and the CD4/CD8 cell ratio) were tightly associated with the estimate of the DNA methylome age. In summary, our data demonstrate that the general level of Delta-cAge-DNAmAge is fixed before adulthood and appears to be quite stationary thereafter, even in the oldest-old ages. Moreover, the blood DNAmAge estimate seems to be tightly associated with ageing-associated shifts in blood cell composition, especially with those that are the hallmarks of immunosenescence. Overall, these observations contribute to the understanding of the longitudinal aspects of the DNAmAge estimate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据