期刊
BIOELECTROMAGNETICS
卷 36, 期 6, 页码 410-419出版社
WILEY
DOI: 10.1002/bem.21921
关键词
peripheral neuromodulation; neuropathic pain; non-invasive neuromodulation; TMS; TENS
Peripheral nerve injury diminishes fast conducting large myelinated afferent fibers transmission but enhances smaller pain transmitting fibers firing. This aberrant afferent neuronal behavior contributes to development of chronic post-traumatic peripheral neuropathic pain (PTP-NP). Non-invasive dynamic magnetic flux stimulation has been implicated in treating PTP-NP, a condition currently not adequately addressed by other therapies including transcutaneous electrical nerve stimulation (TENS). The current study assessed the effect of low frequency transcutaneous magnetic stimulation (LFTMS) on peripheral sensory thresholds, nerve conduction properties, and TENS induced fast afferent slowing effect as measured by motor and sensory conduction studies in the ulnar nerve. Results indicated sham LFTMS with TENS (Sham+TENS) significantly (P=0.02 and 0.007, respectively) reduces sensory conduction velocity (CV) and increases sensory onset latency (OL), and motor peak latency (PL) whereas, real LFTMS with TENS (Real+TENS) reverses effects of TENS on sensory CV and OL, and significantly (P=0.036) increases the sensory PL. LFTMS alone significantly (P<0.05) elevates sensory PL and onset-to-peak latency. LFTMS appears to reverse TENS slowing effect on fast conducting fibers and casts a selective peripheral modulatory effect on slow conducting pain afferent fibers. Bioelectromagnetics. 36:410-419, 2015. (c) 2015 Wiley Periodicals, Inc.
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