期刊
BIOELECTROMAGNETICS
卷 36, 期 5, 页码 386-397出版社
WILEY
DOI: 10.1002/bem.21917
关键词
axons; pulsed magnetic fields; sodium channel; potassium channel
资金
- Professional Staff Congress City University of New York (PSC CUNY) [6561400-43]
This paper investigates the influence of pulsed magnetic fields (PMFs) on amplitude of evoked, compound action potential (CAP) recorded from the segments of sciatic nerve in vitro. PMFs were applied for 30min at frequency of 0.16Hz and intensity of 15mT. In confirmation of our previous reports, PMF exposure enhanced amplitude of CAPs. The effect persisted beyond PMF activation period. As expected, CAP amplitude was attenuated by antagonists of sodium channel, lidocaine, and tetrodotoxin. Depression of the potential by sodium channels antagonists was reversed by subsequent exposure to PMFs. The effect of elevated potassium concentration and veratridine on the action potential was modified by exposure to PMFs as well. Neither inhibitors of protein kinase C and protein kinase A, nor known free radicals scavengers had any effects on PMF action. Possible mechanisms of PMF action are discussed. Bioelectromagnetics. 36:386-397, 2015. (c) 2015 Wiley Periodicals, Inc.
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