期刊
AFRICAN HEALTH SCIENCES
卷 15, 期 4, 页码 1277-1281出版社
MAKERERE UNIV, COLL HEALTH SCIENCES,SCH MED
DOI: 10.4314/ahs.v15i4.29
关键词
Aminoglycoside-modifying enzymes; antibiotics resistance; Pseudomonas aeruginosa
资金
- TWAS/CSIR PG Fellowship
Background: Enzymatic modification of aminoglycosides is the primary mechanism of resistance by Pseudomonas aeruginosa. Obejectives: We investigated the occurrence and mechanism of aminoglycosides resistance in P. aeruginosa isolates from hospitals in SouthWest Nigeria. Methods: A total of 54 consecutive, non-duplicate clinical isolates of P. aeruginosa were studied for the presence of aminoglycosides -modifying enzymes (AMEs) by PCR amplification and sequencing of genes encoding AMEs. Results and conclusion: Two types of AME genes [aac (6') - I and ant (2'') - I] were found in 12 isolates out of 54. Seven strains harboured one or more types of enzymes of which aac (6') - I was the most frequently found gene (10/54 isolates, 18.5%). None of the isolates investigated in this study were positive for aph, aac (3) and aac (6'') - II genes. Prevalence of P. aeruginosa producing AME genes in this study may suggest aminoglycosides use in Nigeria. This study highlights need for functional antimicrobial surveillance system in Nigeria.
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