期刊
ADVANCES IN THERAPY
卷 34, 期 2, 页码 324-356出版社
SPRINGER
DOI: 10.1007/s12325-016-0451-1
关键词
Antibody-dependent cell-mediated cytotoxicity; B-cell lymphoma; CD20; Chronic lymphocytic leukemia; Glycoengineering; Monoclonal antibody; Non-Hodgkin lymphoma; Obinutuzumab; Oncology; Rituximab
资金
- Chugai Pharmaceutical Co., Ltd., Chuo-ku, Tokyo, Japan
- Chugai Pharmaceutical Co., Ltd.
Obinutuzumab (GA101) is a novel, type II, glycoengineered, humanized anti-CD20 monoclonal antibody that has been developed to address the need for new therapeutics with improved efficacy in patients with lymphocytic leukemia and lymphoma of B-cell origin. Obinutuzumab has a distinct mode of action relative to type I anti-CD20 antibodies, such as rituximab, working primarily by inducing direct cell death and antibody-dependent cell-mediated cytotoxicity. Obinutuzumab is under investigation in a wide-ranging program of clinical trials in patients with B-cell malignancies. Efficacy as monotherapy has been reported in patients with relapsed/refractory indolent and aggressive non-Hodgkin lymphoma (NHL) and in chronic lymphocytic leukemia (CLL) of B-cell origin. Improved outcomes have also been noted when obinutuzumab is added to chemotherapy in patients with B-cell NHL, and superiority over rituximab has been reported with combination therapy in patients with CLL. Ongoing research is focusing on developing options for chemotherapy-free treatment and on new combinations of obinutuzumab with novel targeted agents.
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