期刊
ADVANCES IN ANATOMIC PATHOLOGY
卷 23, 期 3, 页码 144-158出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PAP.0000000000000112
关键词
acute liver failure; fulminant hepatitis; drug hepatotoxicity; acetaminophen; ductular reaction
类别
Acute liver failure (ALF) is a rare and severe liver disease that usually develops in 8 weeks or less in individuals without preexisting liver disease. Its chief causes worldwide are hepatitis virus infections (hepatitis A, B, and E) and drug hepatotoxicity (particularly intentional or unintentional acetaminophen toxicity). Massive hepatic necrosis is often seen in liver specimens in ALF and features marked loss of hepatocytes, variable degrees of inflammation, and a stereotypic proliferation of bile ductular structures (neocholangioles) derived from activated periportal hepatic progenitor cells. This paper reviews the liver pathology in ALF, including forms of zonal necrosis and their etiologies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据