期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 358, 期 21, 页码 3350-3354出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201600680
关键词
carbonylation; C-H activation; domino reactions; heterocycle synthesis; quinolin-2(1H)-ones
资金
- Chinese Scholarship Council
Quinolin-2(1H)-ones are important chemicals with various applications in pharmaceuticals. In this communication, we have developed a novel and efficient iridium-catalyzed carbonylative annulation of simple anilines with internal alkynes for the straightforward synthesis of halogen-containing quinolin-2(1H)-ones. The reaction proceeds without preactivation and directing groups through direct N-H and C-H bond activation with a broad substrate scope and high efficiency. Halogen functional groups can be well tolerated here. Remarkably, this is the first example of an iridium-catalyzed carbonylative C-H activation of anilines.
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