期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 358, 期 24, 页码 3971-3976出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201601070
关键词
asymmetric catalysis; Cinchona alkaloids; hydroxylation; pyrazolones
资金
- National Natural Science Foundation of China [21542007]
- Program for New Century Excellent Talents in University [NCET-11-0053]
- Fundamental Research Funds of the Central Universities [DUT15TD25]
A natural quinine-catalyzed, efficient and practical asymmetric -hydroxylation of 4-substituted pyrazolones has been developed, delivering a broad spectrum of pyrazolones bearing an oxygen-attached carbon stereocenter at C-4 in high yields and excellent enantioselectivities. The broad substrate scope, ready availability of the catalyst, ease of operation, and valuable transformation of the product highlight the practical utility of this process.
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