期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 358, 期 5, 页码 746-751出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500965
关键词
divergent synthesis; heterocycles; radicals; trifluoromethylation; unactivated alkenes
资金
- National Nature Science Foundation of China [21202143, 21472163]
Most of the precedent copper-catalyzed trifluoromethylation reactions of unactivated alkenes concern terminal alkenes, and these processes are terminated in elimination, or nucleophilic addition, or semipinacol rearrangement, or C-H bond functionalization steps. In this study, we develop a trifluoromethylation method for both unactivated terminal and internal alkenes to enable divergent late-stage radical cyclization and achieve high molecular complexity. These cyclizations are well consistent with Baldwin I s rule. Furthermore, a kinetic isotope effect (KIE) study and control reactions were conducted, and a plausible mechanism is proposed.
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