期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 358, 期 21, 页码 3450-3457出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201600675
关键词
C-H functionalization; copper; enamines; internal olefins; thiolactones
资金
- National Basic Research Program of China [2015CB856600]
- National Natural Science Foundation of China [21472185]
A copper(I)-catalyzed, (diacetoxyiodo)benzene [PhI(OAc)(2)]-mediated ring-expansion/thiolactonization of alpha-oxo ketene dithioacetals was efficiently realized via azidation of the internal olefinic C-H bond with sodium azide under mild conditions. Sequential amination, ring-expansion rearrangement, and thiolactonization occurred to form aminated thiolactones in the presence of acetic anhydride as the additive, while only C-H amination to afford the unprotected enamines occurred when using ammonium sulfide as a reducing additive. The in situ generated vinyl azides were confirmed as the reactive intermediates, which were captured by phenylacetylene to produce triazoles. This protocol provides a concise route to thiolactone derivatives and unprotected enamines.
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