期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 358, 期 15, 页码 2385-2391出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201600132
关键词
alpha-amination; alpha-aminocarbonyl compounds; C(sp(3))-H functionalization; copper; oxidative cross-coupling
A novel and selective method for the simple copper-catalyzed alpha-amination of alpha-aminocarbonyl compounds to afford 2-amino-2-iminocarbonyl and 2-amino-2-oxocarbonyl compounds is reported. This transformation is achieved by C(sp3)-H and N-H bond oxidative cross-coupling and selective C-N bond oxidative cleavage. This reaction system has a broad reaction scope, providing a facile pathway for the alpha-functionalization of alpha-amino ketones.
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