期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 358, 期 6, 页码 874-879出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201501025
关键词
asymmetric catalysis; aza-1,4-addition; aza-1,6-addition; spiro-pyrrolidines
资金
- NSFC [21202073, 21290180, 21272097, 21372104, 21472077]
- 111 Program of MOE
- Project of MOST [2012ZX 09201101-003]
- fundamental research funds for the central universities [lzujb-ky-2014-k20, lzujbky-2015-k12]
A spiro-pyrrolidine-catalyzed tandem aza-1,4-addition/hemi-acetalization reaction was developed with excellent enantioselectivity (12 examples of >= 99% ee), and several substrates proceeded with higher ee (up to 10% increase) compared with the literature data. Particularly, an interesting and unusual aza-1,6-/oxa-1,4-addition for some substrates was also observed.
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