期刊
BIOCONJUGATE CHEMISTRY
卷 26, 期 8, 页码 1533-1541出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.5b00156
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资金
- Fondazione CON IL SUD [2011-PDR-20]
- Italian Ministry for Research (M.I.U.R.) FIRB RENAME [RBAP114AMK]
- AIRC [IG 13575]
- UE FP7 THALAMOSS (Thalassemia Modular Stratification System for Personalized Therapy of B-Thalassemia) [306201-FP7-HEALTH-2012- INNOVATION-1]
The delivery of peptide nucleic acids (PNAs) to cells is a very challenging task. We report here that a liposomal formulation composed of egg PC/cholesterol/DSPE-PEG2000 can be loaded, according to different encapsulation techniques, with PNA or fluorescent PNA oligomers. PNA loaded liposomes efficiently and quickly promote the uptake of a PNA targeting the microRNA miR-210 in human erythroleukemic K562 cells. By using this innovative delivery system for PNA, down-regulation of miR-210 is achieved at a low PNA concentration.
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