期刊
ADVANCED MATERIALS
卷 28, 期 34, 页码 7340-7364出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201601498
关键词
hierarchical targeting; stimuli-responsive nanoplatforms; changeable particle sizes; switchable surface charges; activatable surface ligands
类别
资金
- National Science Foundation of China [81401465, 51573096, 81272987]
- Intramural Research Program (IRP) of the NIBIB, NIH
Targeted delivery of therapeutic agents is an important way to improve the therapeutic index and reduce side effects. To design nanoparticles for targeted delivery, both enhanced tumor tissue accumulation/retention and enhanced cellular internalization should be considered simultaneously. So far, there have been very few nanoparticles with immutable structures that can achieve this goal efficiently. Hierarchical targeting, a novel targeting strategy based on stimuli responsiveness, shows good potential to enhance both tumor tissue accumulation/retention and cellular internalization. Here, the recent design and development of hierarchical targeting nanoplatforms, based on changeable particle sizes, switchable surface charges and activatable surface ligands, will be introduced. In general, the targeting moieties in these nanoplatforms are not activated during blood circulation for efficient tumor tissue accumulation, but re-activated by certain internal or external stimuli in the tumor microenvironment for enhanced cellular internalization.
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