4.8 Article

Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy

期刊

ADVANCED MATERIALS
卷 28, 期 17, 页码 3313-3320

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201505869

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资金

  1. NC TraCS, NIH's Clinical and Translational Science Awards (CTSA, NIH Grant) at UNC-CH, National Natural Science Foundation of China [1UL1TR001111, 21174060]
  2. Program for Changjiang Scholars and Innovative Research Team in University [IRT1252]
  3. State of North Carolina
  4. National Science Foundation (NSF)
  5. China Scholarship Council

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A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen (O-1(2)) and inducing hypoxia to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy. This dual-responsive nanocarrier provides an innovative design guideline for enhancing traditional photodynamic therapeutic efficacy integrated with a controlled drug-release modality.

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