4.8 Article

Activatable Photoacoustic Nanoprobes for In Vivo Ratiometric Imaging of Peroxynitrite

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ADVANCED MATERIALS
卷 29, 期 6, 页码 -

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WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201604764

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  1. Nanyang Technological University [NTU-SUG: M4081627.120]
  2. Singapore Ministry of Education [RG133/15: M4011559, RG31/14: M4011276, RG41/14: M401128]
  3. Ministry of Education in Singapore [MOE2014-T2-1-003, MOE2016-T2-1-098, ARC2/15: M4020238]

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Organic semiconducting nanoprobes doped with bulky borane can undergo specific activation by ONOO- even at tumor-relevant acidic pH (6.8), permitting in vivo ratiometric photoacoustic imaging of ONOO- in the tumor environment of living mice.

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